Members of the Food and Health Lab (CEBAS-CSIC) involved in the PolyBiota project recognized as Highly Cited Researchers 2020

Prof. Francisco A. Tomás Barberán, Prof. Juan Carlos Espín de Gea, Dra. Victoria Selma and Dr. Antonio González-Sarrías, members of the Food and Health Lab within the Group of Quality, Safety and Bioactivity of Plant Foods (CEBAS-CSIC) have been included in the prestigious international ranking 'Highly Cited Researchers 2020' elaborated by Clarivate Analytics.

Prof. Tomás Barberán has been included in this ranking since 2015 and Prof. Espín since 2018 (although he was previously included in 2005). Dra. Selma has been included since 2019, while this is the first time for Dr. González-Sarrías.

The Highly Cited Researchers 2020 ranking recognizes the true pioneers in their fields over the last decade, demonstrated by the production of an important number of highly-cited papers that rank in the top 1% by citations for field and year in the Web of Science.

This is the perfect match to accomplish the objectives of the MSCA PolyBiota project.

Sources: La Opinión de Murcia (in Spanish) and Agrodiario (In Spanish)

Publications in SCI Journals

1) Ávila-Gálvez MÁ, Giménez-Bastida JA, Espín JC*, González-Sarrías A* (2020) Dietary Phenolics against Breast Cancer. A Critical Evidence-Based Review and Future Perspectives Int J Mol Sci, 21, 16:5718 (Special Issue "Dietary Bioactive Compounds and Breast Cancer")

2) Danuta Zielińska, Henryk Zieliński, José Moisés Laparra-Llopis, Dorota Szawara-Nowak, Joanna Honke, Juan Antonio Giménez-Bastida (2021) Caffeic acid modulates processes Associated with Intestinal Inflammation Nutrients, 13(2), 554 (Special Issue "Dietary Polyphenols and Their Role in Gut Health")

3) Ávila-Gálvez MÁ, González-Sarrías A, Martínez-Díaz F, Abellán B, Martínez-Torrano AJ, Fernández-López AJ, Giménez-Bastida JA, Espín JC* (2021) Disposition of Dietary Polyphenols in Breast Cancer Patients' Tumors, and their Associated Anticancer Activity: the Particular Case of Curcumin Mol Nutr Food Res, 65(12), e2100163.

4) Giménez-Bastida JA, Ávila-Gálvez MÁ, Espín JC*, González-Sarrías A* (2021) Evidence for Health Properties of Pomegranate Juices and Extracts Beyond Nutrition: A critical Systematic Review of Human Studies Trends Food Scie Nutr, 114, 410-423.

5) Giménez-Bastida JA*, González-Sarrías A*, Laparra-Llopis José Moisés, Schneider C, Espin JC (2021) Targeting Mammalian 5-Lipoxygenase by Dietary Phenolics as an Anti-Inflammatory Mechanism: A Systematic Review Int J Mol Sci, 22(12), 7937 (Topical Collection "Feature Papers in Bioactives and Nutraceuticals")

6) Carlos E. Iglesias-Aguirre, A. Cortes-Martin, M.A. Avila-Galvez, Juan Antonio Giménez-Bastida, Maria V. Selma, Antonio Gonzalez-Sarrias, and Juan Carlos Espin* (2021) Main drivers of (poly)phenols effectson human health: metabolites production and(or) gut microbiota-associatedmetabotypes?, Food Fuct, 12(21), 10324-10355

7) García-Villalba, R. Giménez-Bastida, J.A. Cortés-Martín, A. Avila-Galvez, M.A., Iglesias-Aguirre C.E., Tomás-Barberán, F.A., Selma, M.V., Espín, J.C., González-Sarrías, A.* (2022) Urolithins: a comprehensive update on their metabolism, bioactivity, and associated gut microbiota, Mol Nutr Food Res, Feb 3:e2101019 (doi:10.1002/mnfr.202101019)

8) Giménez-Bastida J.A.*, Ávila-Gálvez M.A., Carmena-Bargueño M., Pérez-Sánchez H., Espín J.C., González-Sarrías A. (2022) Physiologically relevant curcuminoids inhibit angiogenesis via VEGFR2 in human aortic endothelial cells, Food Chem Toxicol, 166:113254 (doi: 10.1016/j.fct.2022.113254)

9) Garcia-Villalba R., Tomás-Barberán, F.A., Iglesias-Aguirre C.E., Giménez-Bastida J.A., González-Sarrías A., Selma M.V., Espín J.C.* (2022) Ellagitannins, urolithins, and neurorotection: Human Evidence and the possible link to the gut microbiota, Mol Aspect Med, 5:101109 (doi: 10.1016/j.mam.2022.101109)

10) Giménez-Bastida J.A.*, Ávila-Gálvez M.A., Martínez-López A., García-Moreno D., Espín J.C., González-Sarrías A.* (2024) (R,S)-Equol 7-b-D-glucuronide, but not other circulating metabolites, modulates migration and tubulogenesis in human aortic endothelial cells targeting the VEGF pathway, Food & Funct, (doi: 10.1039/D3fo03946c)

Objectives PolyBiota project

 

Objectives

Cardiovascular disease (CVD) is the main cause of mortality in Europe with an annual estimated cost of €210 billion. Different European Public Health strategies have targeted diet to prevent/treat CVDs. This multidisciplinary and multi-institutional project aims to provide new insights into the role of the gut microbiota as a key player in the beneficial effects against CVDs associated with the consumption of Polyphenols (PPs)-rich foods. PolyBiota will be developed through innovative research at one of the epicenters of PPs research (CEBAS-CSIC) and secondment at FISABIO (Valencia, Spain). Epidemiological, clinical, and preclinical studies suggest that the consumption of PPs-containing food protects against CVDs (i.e, modulating angiogenesis in atherosclerotic plaques) . However, these benefits are not always observed due to the high inter-individual variability. The gut microbiota has emerged as an essential player that regulates the bioactivity of PPs. Recent clinical trials indicate that the gut microbiota composition play a critical role in the activity of PPs improving CV biomarkers. These studies open a new door to investigate how the interaction PPs-gut microbiota can modulate mechanisms associated with the improvement of CVDs. PolyBiota will investigate: 

i) role of the gut microbiota as mediator of the effects of the consumption of Ellagitannins (ETs)-/urolithin (Uro)-A- and Isoflavones (IsoFlv)-/equol-enriched diets on angiogenesis/mechanisms related in untreated and antibiotic-treated animals 

ii) the “prebiotic-like effect” of the ETs, Uro-A, IsoFlv and equol consumption on the gut microbiota population

iii) the effects of the gut microbiota-biosynthesized messenguers or the ETs- and IsoFlv-derived metabolites on in vitro tubulogenesis. 

PolyBiota shows an innovative approach combining cutting-edge techniques, “big data” management, endothelial cells, and in vivo animal models providing a holistic scene of the Diet-Gut Microbiota-Host interaction.